CACR is proud to announce that two of our employees received recognition at Caltech’s 55th annual Service Awards Ceremony, held in Beckman Auditorium on Wednesday, June 1, 2011.
Many thanks to Julian and John for their service to the institute and to CACR!
Students, postdoctoral fellows and faculty are invited to attend a Keck Institute for Space Studies (KISS) half-day short course entitled:
“Looking for Nuggets in Massive Data Streams”
Tuesday, June 7, 2011
9:00am – 12:30pm
Hameetman Auditorium, Cahill Building
This short course is being held in conjunction with the KISS study “Digging Deeper: Algorithms for Computationally-Limited Searches in Astronomy.”
This series of talks will review some of the tools and techniques used for detection and classification on transient signals in massive data streams in astronomy, e.g., searches for gravitational wave sources, or transient events in synoptic sky surveys. The focus of this short course is on advanced data mining and statistical techniques and algorithms.
Speakers include:
09:15 – 10:15 Signal analysis and parameter estimation in gravitational wave astronomy, Badri Krishnan (AEI)
10:15 – 10:45 Keynote talk: New Developments in Time Series Analysis, Jeff Scargle (NASA Ames)
10:45 – 11:15 Coffee break
11:15 – 11:45 Automated Classification of Transients, Ashish Mahabal (Caltech)
11:45 – 12:15 Machine Learning applications in Time Domain Astronomy, Pavlos Protopapas (CfA)
The short course will be videotaped and made available on the KISS website within two weeks after the workshop is completed.
Seating is limited and is available on a first come, first served basis – and no registration is required. An informal lunch is provided for all short course attendees.
Please see http://www.kiss.caltech.edu for more details.
Co-Sponsored by the Caltech Biological Network Modeling Center (BNMC)
Gustavo Kunde Rohde, Assistant Professor, Biomedical Engineering, Carnegie Mellon University
Monday, May 16, 2011
2:00 PM – 3:00 PM
Beckman Institute Auditorium
Novel biomedical imaging techniques have enabled the acquisition of quantitative information from cells, tissues, and organs with unprecedented accuracy and specificity. Combined with the availability of vast computational resources, quantitative biomedical imaging pipelines have the potential to accelerate scientific discovery and improve clinical practice. An important engineering problem in this area relates to extracting quantitative information related to the form (shape and texture) of cells, tissues, and organs. I will describe our recent efforts toward the development of a general purpose segmentation method and present preliminary evidence that a tool capable of high-enough accuracy for quantitative imaging pipelines may one day be available. In addition, recent efforts in developing geometric data analysis tools for mining morphological information from biomedical image data will be described. In particular, I will describe the application of deformation and transportation related metrics, in combination with discriminant analysis techniques, towards understanding the distribution of cellular patterns in cancerous and normal tissues.
CACR Publication News: Cellcenter collaboration with developmental biologists yields insight in fruit fly genomics
“High resolution mapping of Twist to DNA in Drosophila embryos: Efficient functional analysis and evolutionary conservation” was published in the Genome Research Journal, Advanced Online Access, March 2011. Genome Research focuses on research that provides novel insights into the genome biology of all organisms, including advances in genomic medicine.
From the abstract:
“Cis-regulatory modules (CRMs) function by binding sequence specific transcription factors, but the relationship between in vivo physical binding and the regulatory capacity of factor-bound DNA elements remains uncertain. We investigate this relationship for the well-studied Twist factor in Drosophila melanogaster embryos by analyzing genome-wide factor occupancy and testing the functional significance of Twist occupied regions and motifs within regions … Our results show that high resolution in vivo occupancy data can be used to drive efficient discovery and dissection of global and local cis-regulatory logic.” (more)
CACR staff member Shirley Pepke analyzed the ChIP-seq binding data and found enhanced evolutionary conservation associated with candidate cis regulatory modules.
About Cellcenter: The goal of the Center for Integrative Study of Cell Regulation (Cell Center) is to develop new computational methods for understanding how the many genes and proteins that make up individual cells work together to carry out specialized functions of different cell types, including neurons, plant cells, and bacteria. See www.cellcenter.caltech.edu for further information.
Below are some recent publications and presentations that have been added to CACR’s publications list. See the full list here. You can also subscribe to get notifications of new publications either via our RSS feed or the CACR Twitter feed.
